Article: Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study.
Neither the amplitude nor the decay phase of the spontaneous postsynaptic currents (sPSCs) showed significant change after the various treatments.
Amplitude (control; pA)
Amplitude change (% of the control)
Decay tau (control; ms)
Decay tau change (% of the control)
E2
-37.0 ± 5.0
104.7 ± 3.6
14.9 ± 1.9
129.9 ± 12.4
Faslodex+E2
-33.7 ± 3.9
99.3 ± 4.3
25.4 ± 5.6
148.5 ± 29.5
AM251+E2
-37.4 ± 6.8
112.6 ± 14.1
23.6 ± 4.1
153.9 ± 33.1
THL+E2
-36.3 ± 4.1
101.1 ± 3.6
16.2 ± 1.4
130.3 ± 17.2
The table shows the mean amplitude and decay tau parameters before drug administration and the percentage change in mean amplitudes and decay tau resulting from the drug application.
